Relafen is a non-steroidal anti-inflammatory drug of the arylalkanoic acid family (which includes diclofenac). Marketed under the brand name Relafen, it has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAID's.

Relafen - Pharmacology:

The parent compound is a prodrug, which undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthylacetic acid (6MNA), that is a potent inhibitor of prostaglandin synthesis, most likely through binding to the COX-1 and COX-2 receptors.

Relafen for patients

Relafen is a non-steroidal anti-inflammatory (NSAID) medication used to relieve pain, treat fever, and decrease inflammation and swelling. It is used commonly to treat osteoarthritis and rheumatoid arthritis. This medication should not be used by those with aspirin allergies producing symptoms of difficult breathing, red itching skin. This class of medications has been associated with ulcer and bleeding in the stomach. This is often relieved by taking the medication with food. Water retention may also occur and you should report any swelling of the feet or difficulty breathing to your physician immediately. This medication can be taken with or without food, however, food often alleviates stomach irritation.

Relafen Interactions

In vitro studies have shown that, because of its affinity for protein, 6MNA may displace other protein-bound drugs from their binding site. Caution should be exercised when administering nabumetone with warfarin since interactions have been seen with other NSAIDs.

Concomitant administration of an aluminum-containing antacid had no significant effect in the bioavailability of 6MNA. When administered with food or milk, there is more rapid absorption; however, the total amount of 6MNA in the plasma is unchanged .

Relafen Contraindications

Relafen is contraindicated in patients who have previously exhibited hypersensitivity to it.

Relafen is contraindicated in patients in whom nabumetone, aspirin or other NSAIDs induce asthma, urticaria or other allergic-type reactions. Fatal asthmatic reactions have been reported in such patients receiving NSAIDs.

Generic name, Overdose, Half Life Relafen, Food Interactions, Chemical, etc..

Relafen see also Oats straw

Brand Names containing Nabumetone

Chemical structure:
O O H H H H H H H H H H H H H H H H C15H16O2 2D chemical structure C15H16O2 SVG | 2D structure Nabumetone chemical names, chemical properties, classification C15H16O2