A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. .

Medicinal name:
  • Acebutolol Hydrochloride 400 MG Oral Capsule [Sectral]
  • Acebutolol Hydrochloride 200 MG Oral Capsule [Sectral]

Sectral - Pharmacology:

Sectral is a selective β1-receptor antagonist. Activation of β1-receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Sectral blocks these receptors which reverses the effects of epinephrine, lowering the heart rate and blood pressure. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels.

Sectral mini report

Sectral NDA
NDA - A product marketed under an approved New Drug Application
Sectral global name
acebutolol hydrochloride
Start - Stop data
Start - Stop data
not occurred

Sectral Interactions

Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with beta-blocking agents. Patients treated with acebutolol plus catecholamine depletors should, therefore, be observed closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/presyncope, or orthostatic changes in blood pressure without compensatory tachycardia. Exaggerated hypertensive responses have been reported from the combined use of beta-adrenergic antagonists and alpha-adrenergic stimulants, including those contained in proprietary cold remedies and vasoconstrictive nasal drops. Patients receiving beta-blockers should be warned of this potential hazard.

Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported.

No significant interactions with digoxin, hydrochlorothiazide, hydralazine, sulfinpyrazone, oral contraceptives, tolbutamide, or warfarin have been observed.

Sectral Contraindications

Sectral hydrochloride capsules are contraindicated in: 1) persistently severe bradycardia; 2) second- and third-degree heart block; 3) overt cardiac failure; and 4) cardiogenic shock.

Manufacturers name:

  • Promius Pharma, LLC

Generic name, Overdose, Half Life Sectral, Food Interactions, Chemical, etc..

Sectral see also FDA report

Brand Names containing Acebutolol

Chemical structure:
O N N O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H C18H28N2O4 2D chemical structure C18H28N2O4 SVG | 2D structure Acebutolol chemical names, chemical properties, classification C18H28N2O4