For the treatment of schizophrenia and acute manic episodes associated with bipolar I disorder, as either monotherapy or adjunct therapy to lithium or divalproex.
Seroquel Mechanism Of Action:
The mechanism of action of quetiapine, as with other drugs used to treat schizophrenia, is unknown. However, it is thought that the drug's therapeutic activity in schizophrenia is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) receptor antagonism. Although quetiapine is known to bind other receptors with similar affinity, only the dopamine D2 and serotonin 5HT2 receptor binding is responsible for quetiapine's therapeutic activity in schizophrenia.
Seroquel Drug Interactions:
Erythromycin This macrolide increases the effect/toxicity of quetiapine
Clarithromycin This macrolide increases the effect/toxicity of quetiapine
Rivastigmine Possible antagonism of action
Galantamine Possible antagonism of action
Donepezil Possible antagonism of action
Ethotoin Phenytoin decreases the effect of quetiapine
Fosphenytoin Phenytoin decreases the effect of quetiapine
Mephenytoin Phenytoin decreases the effect of quetiapine
Phenytoin Phenytoin decreases the effect of quetiapine
Ketoconazole Ketoconazole increases effect/toxicity of quetiapine
Quinupristin This combination presents an increased risk of toxicity
Hepatic. The major metabolic pathways are sulfoxidation, mediated by cytochrome P450 3A4 (CYP3A4), and oxidation. The major metabolites of quetiapine are inactive.