Use in Newborn or Premature Infants: This drug should not be used in newborn or premature
Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for
newborns and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
Antihistamines are also contraindicated in the following conditions: Hypersensitivity to diphenhydramine
hydrochloride and other antihistamines of similar chemical structure.
Use as a Local Anesthetic: Because of the risk of local necrosis, this drug in the parenteral from should
not be used as a local anesthetic.