A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. trimethoprim resistance has been reported. .

Sumetrolim - Pharmacology:

Sumetrolim binds to bacterial dihydrofolate reductase, subsequently interfering with the uptake of p-aminobenzoic acid (PABA) into folic acid. As folic acid is a coenzyme responsible for the transport of one-carbon fragments from one molecule to another, it is an essential component of bacterial development. Sulfonamides inhibit bacterial dihydrofolate synthetase, the enzyme immediately preceding dihydrofolate reductase, and therefore act synergistically with trimethoprim.

Sumetrolim Interactions

Sumetrolim may inhibit the hepatic metabolism of phenytoin. Sumetrolim, given at a common clinical dosage, increased the phenytoin half-life by 51% and decreased the phenytoin metabolic clearance rate by 30%. When administering these drugs concurrently, one should be alert for possible excessive phenytoin effect.

Sumetrolim Contraindications

Sumetrolim is contraindicated in individuals hypersensitive to trimethoprim and in those with documented megaloblastic anemia due to folate deficiency.

Generic name, Overdose, Half Life Sumetrolim, Food Interactions, Chemical, etc..

Sumetrolim see also Hops


Chemical structure:
N N O O O N N H H H H H H H H H H H H H H H H H H C14H18N4O3 2D chemical structure C14H18N4O3 SVG | 2D structure chemical names, chemical properties, classification C14H18N4O3