A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.

Medicinal name:
  • Levonorgestrel 1.5 MG Oral Tablet [Take Action]

TAK - Pharmacology:

Ontak binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells.

TAK Interactions

No clinical drug interaction studies have been conducted. However, in a single in vivo rodent study denileukin diftitox had no effect on P450 levels.

TAK Contraindications

ONTAK is contraindicated for use in patients with a known hypersensitivity to denileukin diftitox or any of its components: diphtheria toxin, interleukin-2, or excipients.

Manufacturers name:

  • Teva Womens Health, Inc

Generic name, Overdose, Half Life TAK, Food Interactions, Chemical, etc..

TAK see also

Brand Names containing Denileukin diftitox