Tardan is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Tardan exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

Tardan - Pharmacology:

Tardan blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Tardan for patients

The initial doses of chlorprothixene should be as low as possible (e.g. 30mg at bedtime, 15mg morning dose) and be increased gradually. Patients receiving 90mg daily (and more) of the drug should be hospitalized, particularly during the initial phase of treatment. If chlorprothixene is to be withdrawn, it should not be stopped abruptly, but the dose should be decreased steadily.

Tardan Interactions

Tardan may increase the plasma-level of concomitantly given lithium. In order to avoid lithium intoxication, lithium plasma levels should be monitored closely. If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because chlorprothixene amplifies the therapeutic actions and side-effects of opioids massively. Avoid the concomitant use of chlorprothixene and tramadol (Ultram). Massive seizures may be encountered with this combination. Consider additive sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbituates. Choose particular low doses of these drugs. Exert particular caution in combining chlorprothixene with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma.

Tardan Contraindications

Contraindications include alcohol abuse (adds to the central nervous system (CNS) depressant effects), blood disease, enlarged prostate, glaucoma, heart or blood vessel disease, lung disease, Parkinsons disease, stomach ulcers, urination problems (thioxanthenes may worsen the condition), liver disease (higher blood levels of thioxanthenes may occur, increasing the likelihood of side effects), Reyes syndrome (the risk of liver problems may be increased), and seizure disorders (the risk of seizures may be increased).

Generic name, Overdose, Half Life Tardan, Food Interactions, Chemical, etc..

Tardan see also

Brand Names containing Chlorprothixene

Chemical structure:
S Cl N H H H H H H H H H H H H H H H H H H C18H18ClNS 2D chemical structure C18H18ClNS SVG | 2D structure Chlorprothixene chemical names, chemical properties, classification C18H18ClNS