Terbina hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene epoxidase, an enzyme that is part of the fungal cell wall synthesis pathway.

Medicinal name:
  • Terbinafine 250 MG Oral Tablet
  • Terbinafine (as terbinafine hydrochloride) 250 MG Oral Tablet

Terbina - Pharmacology:

Terbina is hypothesized to act by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes.

Terbina for patients

Patient Information:

Discuss with you doctor about the risks of this medication before taking it.
Do not dring alcohol while you are taking Terbina, because liber problem may
occur. Contack you doctor if you experience any discomforts, for example, nausea, vomiting, loss of appetite,
yellow eys or skin.
Finsh the medication even if you feel better.

Terbina Interactions

In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, and cyclosporine. In vitro studies have also shown that terbinafine inhibits CYP2D6-mediated metabolism. This may be of clinical relevance for compounds predominantly metabolized by this enzyme, such as tricyclic antidepressants, ß-blockers, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAO-Is) Type B, if they have a narrow therapeutic window.

In vivo drug-drug interaction studies conducted in normal volunteer subjects showed that terbinafine does not affect the clearance of antipyrine or digoxin. Terbina decreases the clearance of caffeine by 19%. Terbina increases the clearance of cyclosporine by 15%.

There have been spontaneous reports of increase or decrease in prothrombin times in patients concomitantly taking oral terbinafine and warfarin, however, a causal relationship between LAMISIL® Tablets and these changes has not been established.

Terbina clearance is increased 100% by rifampin, a CyP450 enzyme inducer, and decreased 33% by cimetidine, a CyP450 enzyme inhibitor. Terbina clearance is unaffected by cyclosporine.

There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, theophyllines, phenytoins, thiazide diuretics, beta blockers, and calcium channel blockers.

Terbina Contraindications

LAMISIL® (terbinafine hydrochloride tablets) Tablets are contraindicated in individuals with hypersensitivity to terbinafine or to any other ingredients of the formulation.

Manufacturers name:

  • Harris Pharmaceutical, Inc
  • Preferred Pharmaceuticals, Inc
  • Teva Pharmaceuticals USA Inc
  • Northstar Rx LLC
  • Glenmark Generics Inc, USA
  • American Health Packaging
  • DrReddys Laboratories Limited
  • Exelan Pharmaceuticals Inc
  • Bryant Ranch Prepack
  • AvKARE, Inc
  • Wockhardt Limited
  • Camber Pharmaceuticals, Inc
  • Proficient Rx LP
  • PD-Rx Pharmaceuticals, Inc
  • Lake Erie Medical DBA Quality Care Products LLC
  • Breckenridge Pharmaceutical, Inc
  • Aurobindo Pharma Limited
  • Rebel Distributors Corp
  • Golden State Medical Supply, Inc
  • Wockhardt USA LLC
  • Wockhardt USA, LLC
  • Physicians Total Care, Inc
  • Carilion Materials Management

Generic name, Overdose, Half Life Terbina, Food Interactions, Chemical, etc..

Terbina see also Pink Lotus

Brand Names containing Terbinafine
Anti Fungal

Chemical structure:
N H H H H H H H H H H H H H H H H H H H H H H H H H C21H25N 2D chemical structure C21H25N SVG | 2D structure Terbinafine chemical names, chemical properties, classification C21H25N