A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)

Trapanal - Pharmacology:

Trapanal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Trapanal Interactions

The following drug interactions have been reported with thiopental.

Drug Effect
   Probenecid    Prolonged action of thiopental 
   Diazoxide    Hypotension
   Zimelidine    Trapanal antagonism 
   Opioid analgesics    Decreased antinociceptive action
   Aminophylline     Trapanal antagonism
   Midazolam    Synergism

Trapanal Contraindications

Absolute Contraindications

  • Absence of suitable veins for intravenous administration,
  • hypersensitivity (allergy) to barbiturates and
  • variegate porphyria (South African) or acute intermittent porphyria.

Relative Contraindications

  • Severe cardiovascular disease,
  • hypotension or shock,
  • conditions in which the hypnotic effect may be prolonged or potentiated ó excessive premedication, Addisonís disease, hepatic or renal dysfunction, myxedema, increased blood urea, severe anemia, asthma, myasthenia gravis, and
  • status asthmaticus.

Diluents in Pentothal® Kits

Ready-To-Mix Syringes and Vials
(For preparing solutions of Trapanal Sodium for Injection, USP)

Do not use unless the diluent is clear and the bottle or vial seal or syringe package is undamaged.

Diluents in Pentothal Kits, Ready-to-Mix Syringes or Vials should not be used for fluid or sodium chloride replacement.

Generic name, Overdose, Half Life Trapanal, Food Interactions, Chemical, etc..

Trapanal see also

Brand Names containing Thiopental

Chemical structure:
S H N N O H O H H H H H H H H H H H H H H H H C11H18N2O2S 2D chemical structure C11H18N2O2S SVG | 2D structure Thiopental chemical names, chemical properties, classification C11H18N2O2S