For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy.
Trileptal Mechanism Of Action:
The exact mechanism by which oxcarbazepine exerts its anticonvulsant effect is unknown. It is known that the pharmacological activity of oxcarbazepine occurs primarily through its 10-monohydroxy metabolite (MHD). In vitro studies indicate an MHD-induced blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neuronal membranes, inhibition of repetitive neuronal discharges, and diminution of propagation of synaptic impulses.
Trileptal Drug Interactions:
Cyclosporine Trileptal decreases the effect of cyclosporine
Felodipine Trileptal decreases the levels of felodipine
Mestranol Trileptal decreases the effect of the contraceptive
Ethinyl Estradiol Trileptal decreases the effect of the contraceptive
Ethotoin Trileptal increases the effect of hydantoin
Fosphenytoin Trileptal increases the effect of hydantoin
Mephenytoin Trileptal increases the effect of hydantoin
Phenytoin Trileptal increases the effect of hydantoin
The half-life of the parent is about 2 hours, while the half-life of MHD is about 9 hours, so that MHD is responsible for most anti-epileptic activity.