Ultram

A narcotic analgesic proposed for severe pain. It may be habituating. .
[PubChem].

Medicinal name:
  • 24 HR tramadol hydrochloride 300 MG Extended Release Oral Tablet [Ultram]
  • 24 HR tramadol hydrochloride 100 MG Extended Release Oral Tablet [Ultram]
  • Griseofulvin 250 MG Oral Tablet
  • Tramadol hydrochloride 50 MG Oral Tablet [Ultram]
  • Griseofulvin 125 MG Oral Tablet
  • 24 HR tramadol hydrochloride 200 MG Extended Release Oral Tablet [Ultram]
  • Ultram 50 MG Oral Tablet

Ultram - Pharmacology:

Ultram and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. The analgesic properties of Ultram can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord. The (+) enantiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release. The (-) enantiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors.

Ultram mini report

Ultram NDA
NDA - A product marketed under an approved New Drug Application
Ultram ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Ultram TABLET
TABLET
Ultram TABLET, COATED
TABLET, COATED
Ultram TABLET, EXTENDED RELEASE
TABLET, EXTENDED RELEASE
Ultram HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Ultram global name
Tramadol Hydrochloride
Ultram global name
TRAMADOL HCL
Ultram global name
tramadol hydrochloride
Start - Stop data
START DATA:
2012-Mar-01
Start - Stop data
STOP DATA
not occurred

Ultram Interactions

In vitro studies indicate that tramadol is unlikely to inhibit the CYP3A4-mediated metabolism of other drugs when tramadol is administered concomitantly at therapeutic doses. Ultram does not appear to induce its own metabolism in humans, since observed maximal plasma concentrations after multiple oral doses are higher than expected based on single-dose data. Ultram is a mild inducer of selected drug metabolism pathways measured in animals.

Use With Carbamazepine

Patients taking carbamazepine may have a significantly reduced analgesic effect of ULTRAM. Because carbamazepine increases tramadol metabolism and because of the seizure risk associated with tramadol, concomitant administration of ULTRAM and carbamazepine is not recommended.

Use With Quinidine

Ultram is metabolized to M1 by CYP2D6. Quinidine is a selective inhibitor of that isoenzyme, so that concomitant administration of quinidine and ULTRAM results in increased concentrations of tramadol and reduced concentrations of M1.The clinical consequences of these findings are unknown. In vitro drug interaction studies in human liver microsomes indicate that tramadol has no effect on quinidine metabolism.

Use With Inhibitors of CYP2D6

In vitro drug interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 such as fluoxetine, paroxetine, and amitriptyline could result in some inhibition of the metabolism of tramadol.

Use With Cimetidine

Concomitant administration of ULTRAM with cimetidine does not result in clinically significant changes in tramadol pharmacokinetics. Therefore, no alteration of the ULTRAM dosage regimen is recommended.

Use With MAO Inhibitors

Interactions with MAO Inhibitors, due to interference with detoxification mechanisms, have been reported for some centrally acting drugs.

Use With Digoxin and Warfarin

Post-marketing surveillance has revealed rare reports of digoxin toxicity and alteration of warfarin effect, including elevation of prothrombin times.

Ultram Contraindications

ULTRAM should not be administered to patients who have previously demonstrated hypersensitivity to tramadol, any other component of this product or opioids. ULTRAM is contraindicated in any situation where opioids are contraindicated, including acute intoxication with any of the following: alcohol, hypnotics, narcotics, centrally acting analgesics, opioids or psychotropic drugs. ULTRAM may worsen central nervous system and respiratory depression in these patients.

Manufacturers name:

  • Rebel Distributors Corp
  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • REMEDYREPACK INC
  • RiconPharma LLC
  • A-S Medication Solutions LLC
  • PD-Rx Pharmaceuticals, Inc
  • Physicians Total Care, Inc
  • CorePharma, LLC
  • NORTHWIND PHARMACEUTICALS
  • Janssen Pharmaceuticals, Inc
  • Lake Erie Medical DBA Quality Care Products LLC

Ultram tags categories:

Generic name, Overdose, Half Life Ultram, Food Interactions, Chemical, etc..

Ultram see also FDA report

Brand Names containing Tramadol

Chemical structure:
N O O H H H H H H H H H H H H H H H H H H H H H H H H H C16H25NO2 2D chemical structure C16H25NO2 SVG | 2D structure Tramadol chemical names, chemical properties, classification C16H25NO2