Vermox Indication:

For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Vermox Mechanism Of Action:

Vermox causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Vermox Drug Interactions:

Ethotoin The hydantoin decreases the efficiency of mebendazole
Fosphenytoin The hydantoin decreases the efficiency of mebendazole
Mephenytoin The hydantoin decreases the efficiency of mebendazole
Phenytoin The hydantoin decreases the efficiency of mebendazole

Vermox Food Interactions:

Take with food.
Lipid rich meals may improve absorption.

Vermox Generic Name:


  • Not Available

Drug Type:

Small Molecule; Approved


Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.

Toxicity (Overdose):

Acute oral toxicity (LD50): 620 mg/kg [Mouse]. Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.

Protein Binding:



Primarily hepatic. Primary metabolite is 2-amino-5-benzoylbenzimidazole, but also metabolized to inactive hydroxy and hydroxyamino metabolites. All metabolites are devoid of anthelmintic activity.

Half Life:

2.5 to 5.5 hours (range 2.5 to 9 hours) in patients with normal hepatic function. Approximately 35 hours in patients with impaired hepatic function (cholestasis).

Dosage Forms of Vermox:

Tablet Oral

Chemical IUPAC Name:

methyl N-[6-(benzoyl)-1H-benzimidazol-2-yl]carbamate

Organisms Affected:

Helminthic Microorganisms

Vermox to general, pharmacology

General, pharmacology..
General health