Vesicare (rINN), marketed as solifenacin succinate under the trade name Vesicare, is a urinary antispasmodic of the anticholinergic class. It is used in the treatment of overactive bladder with urge incontinence. ..

Vesicare - Pharmacology:

Vesicare is a competitive muscarinic acetylcholine receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle. By preventing the binding of acetylcholine to these receptors, solifenacin reduces smooth muscle tone in the bladder, allowing the bladder to retain larger volumes of urine and reducing the number of incontinence episodes.

Vesicare mini report

Vesicare NDA
NDA - A product marketed under an approved New Drug Application
Vesicare global name
solifenacin succinate
Start - Stop data
Start - Stop data
not occurred

Medicinal name:

  • Solifenacin succinate 5 MG Oral Tablet
  • Solifenacin succinate 10 MG Oral Tablet

Vesicare for patients

What is Vesicare?

Vesicare is a prescription medicine used in adults to treat the following symptoms due to a condition called overactive bladder:

  • Having to go to the bathroom too often, also called "urinary frequency"
  • Having a strong need to go to the bathroom right away, also called "urgency"
  • Leaking or wetting accidents, also called "urinary incontinence."

Vesicare has not been studied in children.

Who Should Not Use Vesicare?

Do not take Vesicare if you:

  • are not able to empty your bladder (also called "urinary retention")
  • have delayed or slow emptying of your stomach (also called "gastric retention")
  • have an eye problem called "uncontrolled narrow-angle glaucoma"
  • are allergic to Vesicare or any of its ingredients.

What are The Risks?

The most common side effects with Vesicare are:

  • Blurred vision. Use caution while driving or doing dangerous activities until you know how Vesicare affects you.
  • Dry mouth
  • Constipation. Call your doctor if you get severe stomach area (abdominal) pain or become constipated for 3 or more days.
  • Heat prostration due to decreased sweating can occur when drugs such as Vesicare are used in a hot environment.

What Should I Tell My Health Care Professional?

Before you start using Vesicare, tell your health care professional if you:

  • have any stomach or intestinal problems or problems with constipation
  • have trouble emptying your bladder or you have a weak urine stream
  • have an eye problem called narrow angle glaucoma
  • have liver problems
  • have kidney problems
  • are pregnant or trying to become pregnant, or are breastfeeding

Are There Any Interactions With Drugs or Foods?

Vesicare can interact with other medicines. Know the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Keep a list of them to show your health care professional and pharmacist.

  • Take Vesicare exactly as prescribed. Your doctor may prescribe the lowest dose if you have certain medical conditions such as liver or kidney problems.
  • You should take one Vesicare tablet once a day.
  • You should take Vesicare with liquid and swallow the tablet whole.
  • You can take Vesicare with or without food.

Vesicare FDA Approved 11/2004
Patient Information Sheet Revised 05/2005

Vesicare Interactions

Do not exceed a 5 mg daily dose of VESIcare when administered with therapeutic doses of ketoconazole or other potent CYP3A4 inhibitors.

Patients with Congenital or Acquired QT Prolongation

In a study of the effect of solifenacin on the QT interval in 76 healthy women, the QT prolonging effect appeared less with solifenacin 10 mg than with 30 mg (three times the maximum recommended dose), and the effect of solifenacin 30 mg did not appear as large as that of the positive control moxifloxacin at its therapeutic dose. This observation should be considered in clinical decisions to prescribe VESIcare for patients with a known history of QT prolongation or patients who are taking medications known to prolong the QT interval.

Vesicare Contraindications

VESIcare is contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and in patients who have demonstrated hypersensitivity to the drug substance or other components of the product.

Brand Names containing Solifenacin

Related brand
Adverse effect counter

Trusted Medical Info

Known as the Merck-KGaA manual in the US & Canada and as the MSD manual in the rest of the World

Manufacturers name:

  • Astellas Pharma Technologies, Inc
  • Cardinal Health
  • Physicians Total Care, Inc

Generic name, Overdose, Half Life Vesicare, Food Interactions, Chemical, etc..

Vesicare see also Echinacea

Chemical structure:
N N O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C27H32N2O6 2D chemical structure C27H32N2O6 SVG | 2D structure Solifenacin chemical names, chemical properties, classification C27H32N2O6

Picture Vesicare