An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. .

Medicinal name:
  • Ethosuximide 250 MG Oral Capsule [Zarontin]

Zarontin - Pharmacology:

Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Zarontin mini report

Zarontin NDA
NDA - A product marketed under an approved New Drug Application
Zarontin ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Zarontin CAPSULE
Start - Stop data
Start - Stop data
not occurred

Zarontin for patients

Zarontin may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a motor vehicle or other such activity requiring alertness; therefore, the patient should be cautioned accordingly.

Patients taking ethosuximide should be advised of the importance of adhering strictly to the prescribed dosage regimen.

Patients should be instructed to promptly contact their physician if they develop signs and/or symptoms (eg, sore throat, fever), suggesting an infection.

Zarontin Interactions

Since Zarontin (ethosuximide) may interact with concurrently administered antiepileptic drugs, periodic serum level determinations of these drugs may be necessary (eg, ethosuximide may elevate phenytoin serum levels and valproic acid has been reported to both increase and decrease ethosuximide levels).

Zarontin Contraindications

Zarontin should not be used in patients with a history of hypersensitivity to succinimides.

Manufacturers name:

  • Parke-Davis Div of Pfizer Inc

Generic name, Overdose, Half Life Zarontin, Food Interactions, Chemical, etc..

Zarontin see also FDA report

Brand Names containing Ethosuximide

Chemical structure:
O O N H H H H H H H H H H H C7H11NO2 2D chemical structure C7H11NO2 SVG | 2D structure Ethosuximide chemical names, chemical properties, classification C7H11NO2