Zocor Indication:

For the treatment of hypercholesterolemia.

Zocor Mechanism Of Action:

The 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate mevinolinic acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

Zocor Drug Interactions:

Not Available

Zocor Food Interactions:

Avoid drastic changes in dietary habit.
Avoid alcohol.
Avoid taking with grapefruit juice.

Zocor Generic Name:

Synonyms:

  • Not Available

Drug Type:

Small Molecule; Approved

Absorption:

Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.

Toxicity (Overdose):

Not Available

Protein Binding:

Both simvastatin and its b-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.

Biotransformation:

Hepatic, simvastatin is a substrate for CYP3A4.

Half Life:

3 hours

Dosage Forms of Zocor:

Tablet Oral

Chemical IUPAC Name:

[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate

Organisms Affected:

Humans and other mammals

Zocor to general, pharmacology

General, pharmacology..