Zofran Indication:

For treatment of chemotherapy-induced nausea and vomiting

Zofran Mechanism Of Action:

Zofran is a selective serotonin 5-HT3 receptor antagonist. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine, and that the released serotonin then activates 5-HT3 receptors located on vagal efferents to initiate the vomiting reflex. Therefore Zofran works by blocking the reception of serotonin at these 5-HT3 receptors.

Zofran Drug Interactions:

Not Available

Zofran Food Interactions:

Not Available

Zofran Generic Name:


  • Not Available

Drug Type:

Small Molecule; Approved


Ondansetron is well absorbed after oral administration and undergoes limited first-pass metabolism.

Toxicity (Overdose):

Low blood pressure and fainting, sudden blindness, severe constipation

Protein Binding:

70%-76% (Plasma protein binding)



Half Life:

5.7 hours

Dosage Forms of Zofran:

Solution Intravenous
Liquid Oral
Liquid Intravenous
Tablet Oral

Chemical IUPAC Name:


Organisms Affected:

Humans and other mammals

Zofran to general, pharmacology

General, pharmacology..